Polymethylmethacrylate（PMMA）膜を用いた持続血液濾過透析における濾過流量の違いが膜寿命と治療効果に及ぼす影響

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  • Impact of difference in filtration flow rate on continuous hemodiafiltration using polymethylmethacrylate (PMMA) membrane on therapeutic effect and filter life

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<p>We retrospectively compared the effects of treatment conditions between different filtration flow rates (Qf) on filter life as well as those of the treatment itself using a polymethylmethacrylate (PMMA) membrane in patients undergoing continuous hemodiafiltration (CHDF). We used a PMMA membrane in 39 patients undergoing CHDF and classified the patients into one of two groups：low-filtration (LF) group (n=10) and high-filtration (HF) group (n=29). The filter life was significantly longer in the LF group than in the HF group. With respect to parameter changes before and after CHDF, significantly reduced catecholamine index and lactic acid level were found in both groups. As no significant difference was found in the rate of decrease between the groups, improved hemodynamic effects were considered to be equivalent. These findings suggest that improved hemodynamic effects are equivalent if blood purification flow rates are the same, regardless of Qf.</p>

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