Prognostic Implications of N-Terminal Pro-B-Type Natriuretic Peptide in Patients With Non-ST-Elevation Myocardial Infarction
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- Kim Chang Hoon
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Lee Seung Hun
- Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School
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- Kim Hyun Kuk
- Department of Internal Medicine and Cardiovascular Center, Chosun University Hospital, University of Chosun College of Medicine
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- Kim Min Chul
- Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School
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- Kim Ju Han
- Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School
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- Hong Young Joon
- Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School
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- Ahn Young Keun
- Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School
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- Jeong Myung Ho
- Division of Cardiology, Department of Internal Medicine, Heart Center, Chonnam National University Hospital, Chonnam National University Medical School
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- Hur Seung Ho
- Keimyung University Dongsan Medical Center
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- Kim Doo Il
- Department of Cardiology, Inje University Haeundae Baek Hospital, Inje University College of Medicine
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- Chang Kiyuk
- Division of Cardiology, Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea
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- Park Hun Sik
- Department of Internal Medicine, Kyungpook National University Hospital
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- Bae Jang-Whan
- Department of Internal Medicine, College of Medicine, Chungbuk National University
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- Jeong Jin-Ok
- Chungnam National University Hospital, Chungnam National University College of Medicine
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- Park Yong Hwan
- Samsung Changwon Hospital, Sungkyunkwan University School of Medicine
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- Yun Kyeong Ho
- Wonkwang University Hospital
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- Yoon Chang-Hwan
- Seoul National University Bundang Hospital
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- Kim Yisik
- Chonbuk National University Hospital and Chonbuk National University Medical School
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- Hwang Jin-Yong
- Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine
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- Kim Hyo-Soo
- Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital
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- Choi Ki Hong
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Park Taek Kyu
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Yang Jeong Hoon
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Song Young Bin
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Hahn Joo-Yong
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Choi Seung-Hyuk
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Gwon Hyeon-Cheol
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
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- Lee Joo Myung
- Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine
抄録
<p>Background: Limited data exist regarding the prognostic implications of N-terminal pro-B-type natriuretic peptide (NT-proBNP) in patients with non-ST-elevation myocardial infarction (NSTEMI) who undergo percutaneous coronary intervention (PCI).</p><p>Methods and Results: Of 13,104 patients in the nationwide Korea Acute Myocardial Infarction Registry-National Institutes of Health, 3,083 patients with NSTEMI who underwent PCI were included in the present study. The primary endpoint was major adverse cardiovascular events (MACE) at 3 years, a composite of all-cause death, recurrent myocardial infarction, unplanned repeat revascularization, and admission for heart failure. NT-proBNP was measured at the time of initial presentation for the management of NSTEMI, and patients were divided into a low (<700 pg/mL; n=1,813) and high (≥700 pg/mL; n=1,270) NT-proBNP group. The high NT-proBNP group had a significantly higher risk of MACE, driven primarily by a higher risk of cardiac death or admission for heart failure. These results were consistent after confounder adjustment by propensity score matching and inverse probability weighting analysis.</p><p>Conclusions: In patients with NSTEMI who underwent PCI, an initial elevated NT-proBNP concentration was associated with higher risk of MACE at 3 years, driven primarily by higher risks of cardiac death or admission for heart failure. These results suggest that the initial NT-proBNP concentration may have a clinically significant prognostic value in NSTEMI patients undergoing PCI.</p>
収録刊行物
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- Circulation Journal
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Circulation Journal advpub (0), 2024-04-11
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