A nationwide survey of non-IgE-mediated gastrointestinal food allergies in neonates and infants
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- Suzuki Hiroko
- National Research Institute for Child Health and Development, Division of Eosinophilic Gastrointestinal Disorders Todachuo General Hospital, Department of Pediatrics
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- Morisaki Naho
- National Center for Child Health and Development, Department of Social Medicine
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- Nagashima Saori
- National Research Institute for Child Health and Development, Division of Eosinophilic Gastrointestinal Disorders
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- Matsunaga Tamotsu
- Todachuo General Hospital, Department of Pediatrics
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- Matsushita Shoko
- Tokyo Metropolitan Children's Medical Center, Department of Allergy
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- Iino Akira
- Tokyo Metropolitan Children's Medical Center, Department of Allergy
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- Tanaka Yuichiro
- National Center for Child Health and Development, Department of General Pediatrics and Interdisciplinary Medicine
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- Nishimori Hisashi
- Mie Prefectural General Medical Center, Department of Pediatrics
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- Munakata Shun
- Nagano Children's Hospital, Department of Neonatology
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- Kemmochi Manabu
- Kitasato University Hospital, Department of Pediatrics
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- Murakami Yoshitaka
- Ehime Prefectural Imabari Hospital, Department of Pediatrics
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- Sato Miori
- National Center for Child Health and Development, Allergy Center
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- Toyokuni Kenji
- National Center for Child Health and Development, Allergy Center
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- Yamamoto-Hanada Kiwako
- National Center for Child Health and Development, Allergy Center
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- Morita Hideaki
- National Research Institute for Child Health and Development, Department of Allergy and Clinical Immunology
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- Fukuie Tatsuki
- National Center for Child Health and Development, Allergy Center
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- Yamada Yoshiyuki
- Tokai University School of Medicine, Department of Pediatrics
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- Ohtsuka Yoshikazu
- Juntendo University School of Medicine, Department of Pediatrics and Adolescent Medicine
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- Arai Katsuhiro
- National Center for Child Health and Development, Allergy Center National Center for Child Health and Development, Division of Gastroenterology
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- Ohya Yukihiro
- National Center for Child Health and Development, Allergy Center
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- Saito Hirohisa
- National Research Institute for Child Health and Development, Department of Allergy and Clinical Immunology
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- Matsumoto Kenji
- National Research Institute for Child Health and Development, Department of Allergy and Clinical Immunology
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- Nomura Ichiro
- National Research Institute for Child Health and Development, Division of Eosinophilic Gastrointestinal Disorders National Center for Child Health and Development, Allergy Center
抄録
<p>Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFAs) seem to be increasing rapidly worldwide. However, nationwide studies have been limited to food-protein-induced enterocolitis (FPIES) and food-protein-induced allergic proctocolitis (FPIAP), with little attention to other non-IgE-GIFA subgroups. The aim of this study was to elucidate the clinical features of all patients with non-IgE-GIFAs, not just certain subgroups.</p><p>Methods: We conducted a nationwide cross-sectional survey of non-IgE-GIFAs in Japan from April 2015 through March 2016. A questionnaire was sent to hospitals and clinics throughout Japan. The questionnaire asked about the number of physician-diagnosed non-IgE-GIFA patients, the status of fulfillment of the diagnostic criteria, tentative classification into 4 clusters based on the initial symptoms, the day of onset after birth, complications, and the suspected offending food(s).</p><p>Results: The response rate to that questionnaire was 67.6% from hospitals and 47.4% from clinics. Analyses were conducted about “diagnosis-probable” patient cohort (n = 402) and the “diagnosis-confirmed” patients (n = 80). In half of the reported non-IgE-GIFA patients, onset occurred in the neonatal period. The patients were evenly distributed among 4 non-IgE-GIFA clusters. In Cluster 1, with symptoms of vomiting and bloody stool, the onset showed a median of 7 days after birth, which was the earliest among the clusters. Cow's milk was the most common causative food.</p><p>Conclusions: In half of the patients, the onset of non-IgE-GIFAs was in the neonatal period. This highlights the importance of studying the pathogenesis in the fetal and neonatal periods.</p>
収録刊行物
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- Allergology International
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Allergology International 73 (2), 264-274, 2024
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390581301853005952
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可