Unraveling the link between atopic dermatitis and autoimmune diseases in children: Insights from a large-scale cohort study with 15-year follow-up and shared gene ontology analysis
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- Ahn Jungho
- Department of Biochemistry, Research Institute for Basic Medical Science, CHA University School of Medicine
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- Shin Seungyong
- CHA Bundang Medical Center, CHA University School of Medicine
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- Lee Gi Chun
- Department of Computer Science and Engineering, College of Engineering, Konkuk University
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- Han Bo Eun
- Department of Software, Sejong University Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine
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- Lee Eun
- Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School
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- Ha Eun Kyo
- Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital
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- Shin Jeewon
- Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine
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- Lee Won Seok
- Department of Pediatrics, CHA Ilsan Medical Center, CHA University
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- Kim Ju Hee
- Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University
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- Han Man Yong
- Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine
抄録
<p>Background: Atopic dermatitis and autoimmune diseases are highly heritable conditions that may co-occur from an early age.</p><p>Methods: The primary study is a national administrative cohort study involving 499,428 children born in 2002, tracked until 2017. Atopic dermatitis was defined as five or more principal diagnoses of atopic dermatitis and two or more topical steroid prescriptions. We estimated the risks for the occurrence of 41 autoimmune diseases, controlling for risk factors. In addition, we sourced a gene library from the National Library of Medicine to conduct a comprehensive gene ontology. We used Gene Weaver to identify gene set similarity and clustering, and used GeneMania to generate a network for shared genes.</p><p>Results: Exposed and unexposed groups included 39,832 and 159,328 children, respectively. During a mean follow-up of 12 years, the exposed group had an increased risk of autoimmune disease (hazard ratio, 1.27 [95 % confidence interval, 1.23-1.32]) compared to the unexposed group. The hazard ratios of autoimmune illnesses consistently increased with two- and five years lag times and alternative atopic dermatitis definitions. Shared genes between atopic dermatitis and autoimmune diseases were associated with comorbidities such as asthma, bronchiolitis, and specific infections. Genetic interactions of these shared genes revealed clustering in Th1, Th2, Th17, and non-classifiable pathways.</p><p>Conclusions: Atopic dermatitis was significantly associated with an increased risk of subsequent autoimmune disease. we identified the genetically associated disease in atopic dermatitis patients comorbid with autoimmune disease and demonstrated a genetic network between atopic dermatitis and autoimmune diseases.</p>
収録刊行物
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- Allergology International
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Allergology International 73 (2), 243-254, 2024
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390581301853072640
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
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- 抄録ライセンスフラグ
- 使用不可