Chronic Effects of Adaptive Servo-Ventilation Therapy on Mortality and the Urgent Rehospitalization Rate in Patients Experiencing Recurrent Admissions for Heart Failure　― A Multicenter Prospective Observational Study (SAVIOR-L) ―

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  • Fukumoto Yoshihiro
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine
  • Tada Takeshi
    Cardiovascular Medicine, Kurashiki Central Hospital
  • Suzuki Hideaki
    Department of Cardiovascular Medicine, Tohoku University Hospital Department of Brain Sciences, Imperial College London
  • Nishimoto Yuji
    Department of Cardiology, Hyogo Prefectural Amagasaki General Medical Center
  • Moriuchi Kenji
    Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center
  • Arikawa Takuo
    Department of Cardiovascular Medicine, Dokkyo Medical University School of Medicine
  • Adachi Hitoshi
    Division of Cardiology, Gunma Prefectural Cardiovascular Center
  • Momomura Shin-ichi
    Department of Medicine, Saitama Citizens Medical Center
  • Seino Yoshihiko
    Medical Corporation Ryosyu-kai Nippon Medical School
  • Yasumura Yoshio
    Department of Cardiology, Amagasaki Chuo Hospital
  • Yokoyama Hiroyuki
    Yokoyama Medical Clinic
  • Hiasa Go
    Department of Cardiology, Ehime Prefectural Central Hospital
  • Hidaka Takayuki
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University Department of Cardiology, Hiroshima Prefectural Hospital
  • Nohara Shoichiro
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine
  • Okayama Hideki
    Department of Cardiology, Ehime Prefectural Central Hospital
  • Tsutsui Hiroyuki
    School of Medicine and Graduate School, International University of Health and Welfare
  • Kasai Takatoshi
    Department of Cardiovascular Biology and Medicine and Cardiovascular Respiratory Sleep Medicine, Juntendo University Graduate School of Medicine
  • Takata Yoshifumi
    Department of Cardiology, Tokyo Medical University
  • Enomoto Mika
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine
  • Saigusa Yusuke
    Department of Biostatistics, Yokohama City University School of Medicine
  • Yamamoto Kouji
    Department of Biostatistics, Yokohama City University School of Medicine
  • Kinugawa Koichiro
    The Second Department of Internal Medicine, Faculty of Medicine, University of Toyama
  • Kihara Yasuki
    Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University Kobe City Medical Center General Hospital
  • on behalf of the SAVIOR-L Investigators

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<p>Background: This study investigated whether the chronic use of adaptive servo-ventilation (ASV) reduces all-cause mortality and the rate of urgent rehospitalization in patients with heart failure (HF).</p><p>Methods and Results: This multicenter prospective observational study enrolled patients hospitalized for HF in Japan between 2019 and 2020 who were treated either with or without ASV therapy. Of 845 patients, 110 (13%) received chronic ASV at hospital discharge. The primary outcome was a composite of all-cause death and urgent rehospitalization for HF, and was observed in 272 patients over a 1-year follow-up. Following 1:3 sequential propensity score matching, 384 patients were included in the subsequent analysis. The median time to the primary outcome was significantly shorter in the ASV than in non-ASV group (19.7 vs. 34.4 weeks; P=0.013). In contrast, there was no significant difference in the all-cause mortality event-free rate between the 2 groups.</p><p>Conclusions: Chronic use of ASV did not impact all-cause mortality in patients experiencing recurrent admissions for HF.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 88 (5), 692-702, 2024-04-25

    一般社団法人 日本循環器学会

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