Stability of Six Drugs in Elneopa NF Infusion after Passing through Infusion Line
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- Kumagai Takefumi
- Pharmacy Co. Ltd.
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- Yamashita Jun
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Narahara Naoko
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Sato Eiji
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Kihira Yoshitaka
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Fujimura Yoshino
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Kojima Eijiro
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Ogawa Shojiro
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Date Yuko
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- Inoue Hirofumi
- Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
Bibliographic Information
- Other Title
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- エルネオパNF輸液中に混注された6種薬剤の輸液ライン通過後の濃度変化に関する検討
Description
<p>Elneopa NF No. 1 and No. 2 infusions are total parenteral nutrition solutions packaged in four-chambered infusion bags. When Elneopa NF infusions are used as home parenteral nutrition, various drugs are co-injected into the infusion bags to treat patient symptoms. This study evaluated the stability of six drugs, including famotidine, scopolamine butylbromide, furosemide, bromhexine hydrochloride, betamethasone sodium phosphate, and metoclopramide hydrochloride, in the Elneopa NF infusion solutions after passing through the infusion line for 24 hours. We observed no therapeutically significant reductions in famotidine, scopolamine butylbromide, furosemide, betamethasone sodium phosphate, and metoclopramide hydrochloride concentrations in Elneopa NF No. 1 and No. 2 after passing through the infusion line. However, we observed a significant decrease in bromhexine hydrochloride concentration in Elneopa NF No. 1 and No. 2 after passing through the infusion line. Therefore, when bromhexine hydrochloride is co-injected into Elneopa NF, the expected therapeutic effect may not be obtained. Also, it was suggested that there was no conversion to insoluble particulate matter affecting their concentration by the co-injection of 6 drugs. The results of this study provide valuable information on total parenteral nutrition.</p>
Journal
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- The Journal of Community Pharmacy and Pharmaceutical Sciences
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The Journal of Community Pharmacy and Pharmaceutical Sciences 16 (1), 21-28, 2024
Pharmacy Society of Japan
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Details 詳細情報について
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- CRID
- 1390581412164022016
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- ISSN
- 24343242
- 18843077
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- KAKEN
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- Abstract License Flag
- Disallowed
