Current Status of Venous Thromboembolism in Japanese

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  • Hiromatsu Shinichi
    Center of Foot Care and Lower Limb Vascular Disease, Kurume University Medical Center

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  • 日本人における静脈血栓塞栓症の実態

Abstract

<p>Using NDB open data and demographic statistics published by the Japanese government, this review investigates the status of VTE among Japanese people. The average annual number of deaths from pulmonary embolism was 1741.1±31.1 people from 1995 to 2021, with 2011 having the highest number of deaths, at 2034, during the study period, which was thought to be related to the Great Eastern Japan Earthquake. Inferior vena cava filter (IVCF) placement has declined since 2014 during the DOAC era. However, only about 50% of cases have had the IVCF removed. The number of pulmonary artery thrombectomies is rising, a trend that conflicts with the decline in IVCF implantation cases. The number of recipients of designated intractable diseases due to chronic thromboembolic pulmonary hypertension (CTEPH) has increased progressively, and the number of such recipients in 2021 was approximately double that in 2014, In contrast, the number of pulmonary artery thromboendarterectomies has not increased progressively. Iliac femoral vein thrombectomies are on the decline, and there were no cases in 2021. Additionally, in several Japanese VTE registry studies, cancer-related venous thromboembolism accounted for about 30% of cases, Hopefully, all direct oral anticoagulants (DOACs) used for VTE in Japan, where low molecular weight heparin (LMWH) is unavailable, will be indicated on the same reduced dose criteria as nonvalvular atrial fibrillation.</p>

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