Clinical Characteristics of Patients with Cryptococcal Meningitis in Hokkaido: A Case Series
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- Tarisawa Monami
- Department of Neurology, Obihiro Kosei General Hospital, Japan Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Kano Takahiro
- Department of Neurology, Obihiro Kosei General Hospital, Japan
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- Ishimaru Tomoki
- Department of Neurology, Japanese Red Cross Asahikawa Hospital, Japan
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- Nomura Taichi
- Department of Neurology, National Hospital Organization Hokkaido Medical Center, Japan
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- Mizushima Keiichi
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Horiuchi Kazuhiro
- Department of Neurology, Hakodate Municipal Hospital, Japan
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- Iwata Ikuko
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
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- Ura Shigehisa
- Department of Neurology, Japanese Red Cross Asahikawa Hospital, Japan
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- Minami Naoya
- Department of Neurology, National Hospital Organization Hokkaido Medical Center, Japan
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- Hozen Hideki
- Department of Neurology, Obihiro Kosei General Hospital, Japan
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- Yabe Ichiro
- Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan
抄録
<p>We retrospectively reviewed the medical histories, examination results, treatments, and prognoses of nine patients with cryptococcal meningitis who were diagnosed and treated at Hokkaido University Hospital and its affiliated hospitals over the past 10 years. Cryptococcal meningitis can develop even in immunocompetent hosts, and its prognosis is poor owing to diagnostic difficulties and delayed treatment. Although liposomal amphotericin B and oral 5-fluorocytosine are standard therapies, voriconazole or intraventricular administration of amphotericin B may also be considered treatment options for refractory patients. Some patients develop delayed exacerbations owing to immunological mechanisms that require steroid therapy. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (9), 1281-1287, 2024-05-01
一般社団法人 日本内科学会