Clinical presentation of pregnancies in women with myasthenia gravis

Kosuge Yuki, Mayumi Miyuki, Itoh Natsumi, Miyamoto Kazue, Watanabe Makiko, Nishida Keiko, Abe Haruna, Ohara Rena, Obata-Yasuoka Mana, Miyazono Yayoi, Hamada Hiromi, Satoh Toyomi

doi:10.34456/jjspnm.60.1_78

<p> Myasthenia gravis（MG）during pregnancy can have severe eﬀects on both the mother and the infant and require appropriate perinatal management. In this study, we examined the course and perinatal outcome of MG during pregnancy to clarify the pathogenesis and consider optimal pregnancy and delivery management. We retrospectively examined 17 pregnancies（one twin pregnancy）of 11 women with MG at our hospital. All pregnancies occurred > 2 years after MG diagnosis, two women（ﬁve pregnancies）were in remission, and eight women（10 pregnancies）had a history of thymectomy. Suction delivery was performed in one pregnancy（5.9%）and cesarean delivery in three pregnancies（17.6%）（two for obstetric and one for MG）. MG exacerbation during pregnancy occurred only in one case（5.9%）in which the drug was reduced during pregnancy and neonatal transient MG was observed in both twins（11.1%）. There was only one case of MG exacerbation during pregnancy, suggesting that the risk of MG exacerbation due to normal pregnancy and delivery management methods is low if the patient becomes pregnant with a stable disease. Along a planned pregnancy, appropriate drug therapy, careful management during pregnancy, the postpartum period, and the neonate are recommended.</p>

Clinical presentation of pregnancies in women with myasthenia gravis

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