Insulinoma with Hyperprocalcitoninemia and Hypercalcitoninemia Showing Coexpression of Insulin and Calcitonin in Its Tumor Cells
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- Kaketaka Tomoko
- Diabetes Center, Toyonaka Municipal Hospital, Japan
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- Mineo Ikuo
- Diabetes Center, Toyonaka Municipal Hospital, Japan
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- Kimura Yu
- Diabetes Center, Toyonaka Municipal Hospital, Japan
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- Ito Naohiko
- Diabetes Center, Toyonaka Municipal Hospital, Japan
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- Okauchi Yukiyoshi
- Diabetes Center, Toyonaka Municipal Hospital, Japan
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- Tamura Hiromi
- Department of Pathology, Toyonaka Municipal Hospital, Japan
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- Adachi Shiro
- Department of Pathology, Toyonaka Municipal Hospital, Japan
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- Iwahashi Hiromi
- Diabetes Center, Toyonaka Municipal Hospital, Japan
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説明
<p>Neuroendocrine neoplasms can produce multiple hormones that are released into the bloodstream, causing symptoms that vary depending on the type and quantity of hormones involved. We herein report a 63-year-old asymptomatic patient with pancreatic insulinoma who showed marked elevations in circulating calcitonin and procalcitonin levels that returned to normal following surgery. Immunohistochemical analyses confirmed the co-staining of calcitonin and insulin immunoreactivity in the tumor cells, suggesting a calcitonin-producing insulinoma. This insulinoma released calcitonin and a considerable amount of its precursor peptide, procalcitonin, resulting in both hyperprocalcitoninemia and hypercalcitoninemia. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 63 (10), 1415-1420, 2024-05-15
一般社団法人 日本内科学会