The effect of hot-water immersion on skeletal muscle ribosome biogenesis

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  • 入浴が筋力トレーニングによるリボソーム量の増加を促進する可能性
  • ニュウヨク ガ キンリョク トレーニング ニ ヨル リボソームリョウ ノ ゾウカ オ ソクシン スル カノウセイ

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<p>【Background】</p><p>Increasing ribosome content is important for skeletal muscle hypertrophy induced by repeated bouts of resistance exercise (RE). Hot-water immersion (HWI) is a widely used post-exercise recovery strategy. HWI activates the mechanistic target of rapamycin (mTOR) signaling pathway, a key regulator of ribosome biogenesis. However, the effect of HWI on ribosome content is unclear. In the present study, we aimed to investigate the effects of HWI and post-exercise HWI on ribosome content.</p><p>【Methods】</p><p>Male Sprague-Dawley rats were divided into non-HWI and HWI groups. In both groups, the right leg was exercised by electrical stimulation. After RE, both limbs were immersed in hot water (41.2 ± 0.03℃) for 20 min under isoflurane anesthesia in the HWI group. The gastrocnemius muscles were sampled 24 h after RE.</p><p>【Results】</p><p>HWI increased phosphorylation of rpS6 and c-myc mRNA expression. Post-exercise HWI significantly increased TIF-IA mRNA expression. However, neither HWI nor post-exercise HWI enhanced 45S pre-rRNA expression and 28S rRNA and 18S rRNA content, widely used markers of ribosome content. In addition, HWI tended to decrease 28S rRNA and 18S rRNA content.</p><p>【Conclusion】</p><p>The present study suggests that HWI as a post-exercise recovery is not effective in increasing ribosome content.</p>

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