A case of misidentification of <i>Neisseria polysaccharea</i> as <i>Neisseria meningitidis </i>by matrix-assisted laser desorption/ionization time of flight mass spectrometry

DOI
  • Tanaka Saori
    Department of Pediatrics, Kimitsu Chuo Hospital Department of Pediatrics, Chiba Rosai Hospital
  • Iwama Akiko
    Department of Clinical Laboratory, Kimitsu Chuo Hospital
  • Takeuchi Noriko
    Department of Infectious Diseases, Medical Mycology Research Center, Chiba University
  • Ohkusu Misako
    Department of Infectious Diseases, Medical Mycology Research Center, Chiba University
  • Ishiwada Naruhiko
    Department of Infectious Diseases, Medical Mycology Research Center, Chiba University
  • Segawa Shunsuke
    Division of Laboratory Medicine, Chiba University Hospital
  • Hayashi Miyuki
    Department of Pediatrics, Kimitsu Chuo Hospital
  • Suwabe Shinichi
    Department of Pediatrics, Kimitsu Chuo Hospital
  • Ohkusu Kiyofumi
    Department of Microbiology, Tokyo Medical University

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  • 質量分析法で<i>Neisseria polysaccharea</i> を<i>Neisseria meningitidis </i> と誤同定し，臨床的対応に苦慮した1例：質量分析法による菌種同定のピットフォール

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<p>We report the case of 1 year and 5-month-old boy with Kawasaki disease who clinically improved using immunoglobulin therapy. Neisseria species was isolated from his throat culture at the time of admission and identified as Neisseria meningitidis by MALDI-TOF MS. Although the explanation of attending doctor, the guardians worried about his condition and requested reexamination of his throat culture and antibiotic treatment for sterilization of N. meningitidis.They also consulted another medical institute for second opinion. After that, this isolated strain was identified as N. polysaccharea by 16S rRNA and recA gene sequences. MALDI-TOF MS is fast and cost-effective diagnostic tool of clinical microbiology laboratories. However, the result of MALDI-TOF MS should be confirmed with additional tests for N. meningitidis.</p>

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