HFC-152a (1,1-Difluoroethane) inhalation causes a decrease in blood hemoglobin function
-
- Ochi Hiroshi
- Department of Legal Medicine, School of Medicine, Fujita Health University Department of Legal Medicine, Osaka University Graduate School of Medicine
-
- Igarashi Kazuo
- Department of Legal Medicine, Osaka University Graduate School of Medicine Department of Forensic Medicine, Kindai University Faculty of Medicine Department of Research Development, Association of Medicinal Analysis
-
- Matoba Ryoji
- Department of Legal Medicine, Osaka University Graduate School of Medicine
-
- Kakiuchi Yasuhiro
- Department of Forensic Medicine, Kindai University Faculty of Medicine
この論文をさがす
説明
<p>1,1-Difluoroethane (HFC-152a) is widely used as a gas component of electronic and precision instrument propellant cleaners. Although HFC-152a has low toxicity, sudden deaths from the abusive inhalation of HFC-152a-containing products have been observed globally. Two cases of HFC-152-related deaths have been reported as the forensic autopsy case. Moreover, we investigated the biodistribution of HFC-152a in rats to elucidate the mechanism of action of HFC-152a. Wistar Rats (n=10) were exposed to the mixed gas (80% HFC-152a and 20% oxygen). They survived the 5-minute exposure but died from asphyxiation after the 10-minute exposure. No significant differences were observed in the biodistribution of HFC-152a between these two groups. Total hemoglobin (tHb) and oxyhemoglobin saturation (O2Hb) were measured to investigate the influence of HFC-152a on hemoglobin function. HFC-152a did not affect tHb, whereas O2Hb was significantly decreased by exposure to HFC-152a. Carbon monoxide (CO) is known as a typical toxic gas, and toxicity of CO is known to reduce the oxygen-carrying capacity of blood by forming carboxyhemoglobin. Because similar phenomenon like CO occurred when exposed to HFC-152a, it was suggested that the cause of sudden deaths due to HFC-152a inhalation was asphyxia by decreased O2Hb level in blood.</p>
収録刊行物
-
- Medical Mass Spectrometry
-
Medical Mass Spectrometry 7 (1), 71-79, 2023-06-25
一般社団法人 日本医用マススペクトル学会