Exploring the relationship between oral health and multiple health conditions: An outcome-wide approach

  • Kino Shiho
    Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan
  • Tamada Yudai
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan
  • Takeuchi Kenji
    Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan Division of Statistics and Data Science, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan
  • Nakagomi Atsushi
    Department of Social Preventive Medical Sciences, Center for Preventive Medical Sciences, Chiba University, Chiba, Japan
  • Shiba Koichiro
    Department of Epidemiology, Boston University School of Public Health, Boston, the United States
  • Kusama Taro
    Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan Division of Statistics and Data Science, Liaison Center for Innovative Dentistry, Tohoku University Graduate School of Dentistry, Sendai, Japan
  • Yamamoto Takafumi
    Department of International and Community Oral Health, Tohoku University Graduate School of Dentistry, Sendai, Japan Department of Health Promotion, National Institute of Public Health, Saitama, Japan
  • Aida Jun
    Department of Oral Health Promotion, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan

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<p>Purpose: A growing body of evidence suggests that oral health is associated with a wide range of health outcomes; however, opinions tend to vary because of inconsistent findings. This study aimed to simultaneously examine the association between oral health status and multiple health and well-being indicators using outcome-wide epidemiology.</p><p>Methods: Data were obtained from the Japan Gerontological Evaluation Study. Oral health status was categorized as: ≥20 teeth, 10-19 teeth with dental prosthesis, 0-9 teeth with prosthesis, 10-19 teeth without prosthesis, and 0-9 teeth without prosthesis. We examined the associations between oral health status in 2013 and 35 health and well-being outcomes in 2019, including physical/cognitive health, psychological distress, subjective health, social well-being, prosocial/altruistic behaviors, and health behaviors, using two databases (n=32,827 and 15,905).</p><p>Results: Compared to individuals with ≥20 teeth, those with <20 teeth had a 10-33% higher risk of mortality and a 6-14% higher risk of functional disability six years later. Additionally, individuals with fewer than 20 teeth tended to go out less frequently and eat fewer vegetables and fruits. Furthermore, individuals with 0-9 teeth without a prosthesis were more likely to have severe functional disability (risk ratio (RR):1.17, 95% confidence interval (CI):1.05-1.31), engage in fewer intellectual activities (standardized difference: 0.17, 95% CI: 0.10-0.24), and feel more hopeless (RR: 1.21, 95% CI: 1.04-1.41).</p><p>Conclusions: The prevention of tooth loss and prosthodontic treatment may be associated with reduced mortality and functional disability, as well as maintenance of intellectual ability, frequency of going out, and improvements in dietary lifestyle.</p>

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