Toward the development of mRNA-LNP vaccines with reduced adverse reactions

DOI
  • YOSHIOKA Yasuo
    RIMD, Osaka University OTRI, Osaka University Graduate School of Pharmaceutical Sciences, Osaka University CAMaD, Osaka University CiDER, Osaka University MEI, Osaka University The Research Foundation for Microbial Diseases of Osaka University (BIKEN)

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Other Title
  • 副反応の低減したmRNA-LNPワクチンの開発に向けて

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<p>Messenger RNA vaccines based on lipid nanoparticles (mRNA-LNPs) are promising vaccine modalities. However, some mRNA-LNP vaccines frequently cause adverse reactions, including local symptoms such as swelling and pain, and general symptoms such as fever. Therefore, developing mRNA-LNP vaccines with fewer adverse reactions is required. In this presentation, I will introduce our findings on the mechanism of mRNA-LNP vaccine induction of adverse reactions and the mRNA-LNP vaccine project to reduce adverse reactions.</p>

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