レオロジー動態に基づく単一赤血球の変形能推定
書誌事項
- タイトル別名
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- Numerical-experimental estimation of human red blood cell deformability
説明
<p>The deformability of human red blood cells (RBCs), which comprise almost 99% of the cells in whole blood, is largely related not only to pathophysiological blood flow but also to the levels of intracellular compounds. Therefore, statistical estimates of the deformability of individual RBCs are of paramount importance in the clinical diagnosis of blood diseases. Although the micro-scale hydrodynamic interactions of individual RBCs lead to non-Newtonian blood rheology, there is no established method to estimate individual RBC deformability from the rheological data of RBC suspensions, and the possibility of this estimation has not been proven. To address this issue, we conducted an integrated analysis of a model of the rheology of RBC suspensions, coupled with macro-rheological data of human RBCs suspended in plasma. Assuming a non-linear curve of the relative viscosity of the suspensions as a function of the cell volume fraction, the statistical average of the membrane shear elasticity was estimated for individual intact RBCs or hardened RBCs. Both estimated values reproduced well the experimentally observed shear-thinning non-Newtonian behavior in these suspensions. We hereby conclude that our complementary approach makes it possible to estimate the statistical average of individual RBC deformability from macro-rheological data obtained with usual rheometric tests.</p>
収録刊行物
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- 年次大会
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年次大会 2024 (0), J222-03-, 2024
一般社団法人 日本機械学会
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詳細情報 詳細情報について
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- CRID
- 1390585095042914304
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- ISSN
- 24242667
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
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- 抄録ライセンスフラグ
- 使用不可
