A case of myoepithelioma-like tumor of the vulvar region showing infiltrative growth to the dermis

DOI
  • Naito Yu
    Department of Pathology, Konankosei hospital Department of Pathology and Laboratory Medicine, Graduate School of Medicine, Nagoya University Department of Pathology, Nagoya University Hospital
  • Yanagida Eriko
    Department of Pathology, Konankosei hospital
  • Noto Yuki
    Department of Pathology, Konankosei hospital
  • Ando Takuro
    Department of Pathology, Konankosei hospital Department of Pathology and Laboratory Medicine, Graduate School of Medicine, Nagoya University Department of Pathology, Nagoya University Hospital
  • Kawano Tasuku
    Department of Pathology, Konankosei hospital
  • Karube Kennosuke
    Department of Pathology and Laboratory Medicine, Graduate School of Medicine, Nagoya University Department of Pathology, Nagoya University Hospital

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  • 真皮内への局所浸潤性が目立ったmyoepithelioma-like tumor of the vulvar regionの1例

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<p>We report a case of myoepithelioma-like tumor of the vulvar region （MELTVR）.　A woman in her 60s had a 2cm subcutaneous tumor on the perineum.　Histologically, the tumor extended from the subcutaneous tissue to the dermis.　The tumor consisted of the proliferation of spindle-shaped and epithelioid cells with abundant myxoid stroma.　The histology resembled that of soft tissue myoepithelioma;however, immunohistochemically, AE1/AE3 showed very focal and weak positivity, CAM5.2, S-100, and GFAP were negative, and EWSR1 gene rearrangement was absent.　Additional immunohistochemical evaluation was performed, and the diagnosis of MELTVR was confirmed based on the expression of Estrogen receptor and complete loss of SMARCB1 expression.　The infiltrative proliferation into the dermis was a characteristic feature of this case.　In addition, we report on MELTVR from the perspective of tumors that show loss of SMARCB1 expression, along with a discussion of the literature.</p>

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