A case of thoracic metastasis from urothelial carcinoma of the right ureter with eosinophilic cytoplasmic inclusions in pleural effusion

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  • NARITOMI Mari
    Department of Pathology, Kawasaki Medical University General Medical Center
  • HATA Sakae
    Department of Medical Technology, Kobe Tokiwa University Faculty of Health Sciences
  • TAKASUGA Hirohisa
    Department of Pathology, Kawasaki Medical University General Medical Center
  • HINO Hiroko
    Department of Pathology, Kawasaki Medical University General Medical Center
  • MONOBE Yasumasa
    Department of Pathology, Kawasaki Medical University General Medical Center

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  • 胸水細胞診標本で好酸性細胞質封入体 (eosinophilic cytoplasmic inclusions) を認めた右尿管原発尿路上皮癌の 1 例

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<p>Background : We report herein on a case of metastatic urothelial carcinoma with eosinophilic cytoplasmic inclusions in the pleural effusion.</p><p>Case : A man in his 60 s presented with hematuria. Computed tomography revealed a tumor in the right ureter. A nephroureterectomy was performed under the diagnosis of carcinoma of the right ureter. About one year later, cytology was performed because there was pooling of right pleural effusion. Cytology showed atypical cells, both singly and in clusters. The atypical cells contained clear cytoplasm and round nuclei with eccentric nucleoli. Twenty-eight percent of atypical cells were found both within and outside of the eosinophilic cytoplasmic inclusions. The inclusions demonstrated metachromasy under Giemsa staining and were both PAS and Alcian blue positive. The inclusions, prepared in a cell block and subjected to immunohistochemistry, showed positivity for CK 7, CD10, CD138, MUC1, E-cadherin and laminin.</p><p>Conclusion : In this rare case of thoracic dissemination of urothelial carcinoma, eosinophilic cytoplasmic inclusions consisting of basement membrane-like components were found in the cytoplasm. Based on our findings, we believe it is necessary to gather more cases and study the diagnostic utility of eosinophilic cytoplasmic inclusions.</p>

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