Rs4968309 in Myosin Light Chain 4 (MYL4) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease

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  • Zhong Yuan
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Tang Kai
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Li Hailing
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Zhao Dongdong
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Kou Wenxin
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Xu Shaojie
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Zhang Jun
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Yang Haotian
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Li Shuang
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Guo Rong
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Peng Wenhui
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
  • Xu Yawei
    Department of Cardiology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine

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  • Rs4968309 in Myosin Light Chain 4 (<i>MYL4</i>) Associated With Atrial Fibrillation Onset and Predicts Clinical Outcomes After Catheter Ablation in Atrial Fibrillation Patients Without Structural Heart Disease

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<p>Background:Atrial fibrillation (AF) is the most common arrhythmia with serious complications and a high rate of recurrence after catheter ablation. Recently, mutation ofMYL4was reported as responsible for familial atrial cardiomyopathy and AF. This study aimed to determine the association between polymorphism inMYL4with the onset and recurrence of AF.</p><p>Methods and Results:A total of 7 single-nucleotide polymorphisms were selected by linkage disequilibrium and genotyped in 510 consecutive AF patients and 192 controls without structural heart disease. A total of 246 AF patients who underwent cryoballoon ablation had a 1-year scheduled follow-up study for AF recurrence. C allele and CC genotype of rs4968309 and A allele of rs1515751were associated with AF onset both before and after adjustment of covariation (age, sex, hypertension, and diabetes). AF type and left atrial size were different among the genotypes of rs4968309. Moreover, CC genotype of rs4968309 increased susceptibly of AF recurrence after cryoballoon ablation. The prevalence of hypertension was associated with rs1515752, and left atrial size was associated with the genotype of rs2071438.</p><p>Conclusions:C allele and CC genotype of rs4968309 inMYL4were associated with AF onset and recurrence. Moreover, the A allele of rs1515751 had a significant association with AF onset. The polymorphisms ofMYL4can predict AF onset and prognosis after ablation in AF patients without structural heart disease.</p>

収録刊行物

  • Circulation Journal

    Circulation Journal 83 (10), 1994-2001, 2019-09-25

    一般社団法人 日本循環器学会

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