Drug Delivery System Using a Solid-in-oil-in-water (S/O/W) Multiple Emulsion
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- TAHARA Yoshiro
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
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- GOTO Masahiro
- Department of Applied Chemistry, Graduate School of Engineering, Kyushu University
Bibliographic Information
- Other Title
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- Solid-in-oil-in-water(S/O/W)型多層エマルションとDDS への応用
- Solid-in-oil-in-water (S/O/W)カタ タソウ エマルション ト DDS エ ノ オウヨウ
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Abstract
<p>Solid-in-Oil (S/O) nanodispersion is a novel emulsion formulation, in which hydrophilic macromolecular drugs are coated with hydrophobic surfactants and dispersed in an oil phase as nano-ordered particles. In this review, history and classification of S/O nanodispersions are described. The main topic of this review is a solid-in-oil-in-water (S/O/W) emulsion that is a multiple-emulsion using a S/O nanodispersion as an oil phase of oil-in-water emulsions. The first study using the S/O/W emulsion in a drug delivery system was focused on the carrier of oral delivery. Insulin was encapsulated in the S/O/W emulsion and released in a gastric condition. In the transdermal delivery, the S/O nanodispersion is known to be effective because skin has a hydrophobic barrier and the S/O/W emulsion is also applied to the transdermal drug delivery as a water-based formulation. In addition, the S/O/W emulsion was used as an encapsulation tool for gene or proteins. The double-coating carrier was effective for the intracellular delivery of gene or proteins. These results suggested that the S/O/W multiple emulsion would be a promising carrier for the drug delivery system of biomolecules.</p>
Journal
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- Oleoscience
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Oleoscience 19 (5), 191-196, 2019
Japan Oil Chemists' Society
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Keywords
Details 詳細情報について
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- CRID
- 1390845702284383744
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- NII Article ID
- 130007711527
- 40021909102
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- NII Book ID
- AA11503417
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- ISSN
- 21873461
- 13458949
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- NDL BIB ID
- 029715190
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed