Reconstitution of the hematopoietic system and clinical applications of iPS cells

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  • SUGIMOTO Naoshi
    Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University
  • ETO Koji
    Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University Department of Regenerative Medicine, Chiba University Graduate School of Medicine

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Other Title
  • iPS細胞技術を用いた造血システムの再構成と治療への応用
  • iPS サイボウ ギジュツ オ モチイタ ゾウケツ システム ノ サイコウセイ ト チリョウ エ ノ オウヨウ

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Abstract

<p>Human iPS cells are somatic cells reprogrammed to the pluripotent state. Because of their pluripotent nature, iPS cells are now commonly used to model several developmental processes including hematopoiesis in vitro. The in vitro models can be used to study the mechanisms regulating not only normal hematopoiesis but also hematological diseases ranging from monogenic congenital disorders to genetically multifactorial malignancies. Those disease models can also be used to investigate novel treatments through procedures including high throughput drug screening. The possible clinical applications of iPS cell-derived hematopoietic cells include immunotherapy with T lymphocytes, NK cells and macrophages, and transfusion therapy with platelets and red blood cells. Platelets have now been produced from iPS cells in quantities sufficient for clinical use. By developing expandable immortalized megakaryocyte cell lines (imMKCLs), several novel drugs and turbulence-incorporated bioreactors, efficient and scalable generation of platelets was achieved. This review summarizes the current status of iPS cell research in hematopoiesis with details on iPS cell-derived platelets.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 60 (9), 1046-1055, 2019

    The Japanese Society of Hematology

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