Clinical Efficacy of Oral Amoxicillin 1,500mg in the Treatment of Syphilis

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  • IKEUCHI Kazuhiko
    Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
  • FUKUSHIMA Kazuaki
    Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
  • TANAKA Masaru
    Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
  • YAJIMA Keishiro
    Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital
  • SEKIYA Noritaka
    Department of Infection Prevention and Control, Tokyo Metropolitan Komagome Hospital
  • SEKIYA Ryoko
    Department of Clinical Laboratory Medicine, Tokyo Medical University Hospital
  • YANAGISAWA Naoki
    Center for Health and the Global Environment, Department of Environmental Health, Harvard T.H. Chan School of Public Health
  • AJISAWA Atsushi
    Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital Toshima Hospital, Tokyo Metropolitan Health and Medical Treatment Corporation
  • IMAMURA Akifumi
    Department of Infectious Diseases, Tokyo Metropolitan Komagome Hospital

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Other Title
  • 梅毒に対するアモキシシリン1,500mg 内服治療の臨床的効果
  • バイドク ニ タイスル アモキシシリン 1,500mg ナイフク チリョウ ノ リンショウテキ コウカ

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Description

<p> Although intramuscular benzathine penicillin G is a standard treatment for syphilis in many countries,it is not available in Japan. Instead, The Japanese Society for Sexually Transmitted Diseases recommends a therapeutic regimen using 1,500mg of oral amoxicillin (AMPC) for syphilis treatment. However, the efficacy of this treatment regimen has not been evaluated sufficiently in the past literature. We conducted a retrospective observational study including 63 patients who were diagnosed as having syphilis (47 HIV patients；median age 40 years) and treated with 1,500mg of oral AMPC. Treatment success was defined as a 4-fold decline in the rapid plasma reagin (RPR) titer within one year after the initiation of the treatment. The overall treatment efficacy was 95.2% (95% confidence interval (CI), 86.7-99.0%). The efficacy for HIV patients, non-HIV patients, early syphilis and late syphilis was 95.7% (95% CI, 85.5-99.5%), 93.8% (95% CI, 69.8- 99.8%), 97.8% (95% CI, 88.5-99.9%) and 88.2% (95% CI, 63.6-98.5%), respectively. Our data suggests that 1,500 mg of oral AMPC was shown to be effective for syphilis.</p>

Journal

  • Kansenshogaku Zasshi

    Kansenshogaku Zasshi 92 (3), 358-364, 2018-05-20

    The Japanese Association for Infectious Diseases

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