触媒的タンパク質チロシン残基の化学修飾法の開発と応用

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  • 佐藤 伸一
    東京工業大学科学技術創成研究院化学生命科学研究所

書誌事項

タイトル別名
  • Development and Application of Catalytic Tyrosine Chemical Modification
  • Review for award 触媒的タンパク質チロシン残基の化学修飾法の開発と応用
  • Review for award ショクバイテキ タンパクシツ チロシンザンキ ノ カガク シュウショクホウ ノ カイハツ ト オウヨウ

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<p>The chemical labeling of proteins with synthetic small compounds is a key technique in chemical biology, protein-based therapy, and material science. Much of the chemical labeling of native proteins, however, depends on the labeling of lysine and cysteine residues. While those methods have contributed significantly to native protein labeling, alternative methods that can modify different amino acid residues are still required. Here we report the development of a novel methodology of oxidative tyrosine labeling, which was inspired by the single-electron transfer reaction in biological systems. The tyrosine labeling methods were developed using small compounds such as N-methyl luminol derivative, N′-acyl-N,N-phenylenediamine, and 1-methyl-4-aryl-urazole under labeling conditions using a hemin, peroxidase, or ruthenium photocatalyst. These methods were applied to target- and site-selective protein modification.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 139 (11), 1365-1375, 2019-11-01

    公益社団法人 日本薬学会

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