The promise of zebrafish as a model of metabolic syndrome

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  • Benchoula Khaled
    Department of Basic Medical Sciences, Kulliyyah of Pharmacy, International Islamic University Malaysia, Sultan Ahmad Shah Street, Kuantan 25200, Pahang, Malaysia
  • Khatib Alfi
    Pharmacognosy Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Sultan Ahmad Shah Street, Kuantan 25200, Pahang, Malaysia Central Research and Animal Facility (CREAM), Kulliyyah of Science, International Islamic University Malaysia, Sultan Ahamad Shah Street, Kuantan 25200, Pahang, Malaysia
  • Jaffar Ashika
    School of Biosciences & Technology, VIT University, Vellore 632014, India
  • Ahmed Qamar Udin
    Pharmacognosy Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Sultan Ahmad Shah Street, Kuantan 25200, Pahang, Malaysia
  • Sulaiman Wan Mohd Azizi Wan
    Department of Basic Medical Sciences, Kulliyyah of Pharmacy, International Islamic University Malaysia, Sultan Ahmad Shah Street, Kuantan 25200, Pahang, Malaysia
  • Wahab Ridhwan Abd
    Kulliyah of Allied Health Science, International Islamic University Malaysia, Sultan Ahmad Shah Street, Kuantan 25200, Pahang, Malaysia
  • El-Seedi Hesham R.
    Pharmacognosy Group, Department of Medicinal Chemistry, Biomedical Centre, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden Alrayan Medical colleges, Medina 42541, Kingdom of Saudi Arabia

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  • Young Investigator Award : The promise of zebrafish as a model of metabolic syndrome

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Abstract

<p>Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and larvae that allow easier visualization. This review discusses how zebrafish models contribute to the development of metabolic syndrome studies. Different diseases in the cluster of metabolic syndrome, such as hyperglycaemia, obesity, diabetes, and hypertriglyceridaemia, have been successfully studied using zebrafish; and the model is promising for hypertension and cardiovascular metabolic-related diseases due to its genetic similarity to mammals. Genetic mutation, chemical induction, and dietary alteration are among the tools used to improve zebrafish models. This field is expanding, and thus, more effective and efficient techniques are currently developed to fulfil the increasing demand for thorough investigations.</p>

Journal

  • Experimental Animals

    Experimental Animals 68 (4), 407-416, 2019

    Japanese Association for Laboratory Animal Science

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