Umbilical cord blood transplantation for a child with very severe aplastic anemia refractory to immunosuppressive treatment

DOI Open Access
  • Mitani Yuichi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
  • Seki Masafumi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
  • Kizawa Mami
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
  • Hidaka Moe
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
  • Fujimura Junya
    Department of Pediatrics and Adolescent Medicine, Juntendo University Hospital
  • Hiwatari Mitsuteru
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo
  • Takita Junko
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo Department of Pediatrics, Kyoto University Hospital

Bibliographic Information

Other Title
  • IST不応の小児最重症再生不良性貧血に対する臍帯血移植例

Search this article

Description

<p>It is a great challenge to treat patients with very severe aplastic anemia (VSAA), who lack an HLA-matched related donor, and who fail to respond to immunosuppressive treatment (IST). Although cord blood transplantation (CBT) is a treatment option for hematological malignancies in the absence of a suitable unrelated donor, there is no evidence so far of the effectivity of CBT for aplastic anemia (AA). We performed semiurgent CBT to control recurrent infections in a patient with VSAA, which was refractory to IST and complicated by infections. The conditioning regimen consisted of fludarabine, melphalan, and low-dose total body irradiation, and GVHD prophylaxis consisted of tacrolimus and mycophenolate mofetil. Neutrophil engraftment was achieved on day 16. Complications such as Grade I acute GVHD, hemophagocytic syndrome, and virus-associated hemorrhagic cystitis were observed; however, they were tolerable. CBT could be an alternative treatment option for VSAA in the absence of an unrelated donor.</p>

Journal

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top