A Case of Gitelman Syndrome that Was Difficult to Distinguish from Hypokalemic Periodic Paralysis Caused by Graves' Disease
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- Oba Takeshi
- Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School
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- Kobayashi Shunsuke
- Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School
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- Nakamura Yuko
- Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School
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- Nagao Mototsugu
- Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School
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- Nozu Kandai
- Department of Pediatrics, Kobe University Graduate School of Medicine
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- Fukuda Izumi
- Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School
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- Iijima Kazumoto
- Department of Pediatrics, Kobe University Graduate School of Medicine
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- Sugihara Hitoshi
- Department of Endocrinology, Diabetes and Metabolism, Graduate School of Medicine, Nippon Medical School
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抄録
<p>A 21-year-old man presented with hyperthyroidism and hypokalemia and was treated for thyrotoxic hypokalemic periodic paralysis caused by Graves' disease. Thyroid function soon normalized but hypokalemia persisted. Laboratory data revealed hyperreninemic hyperaldosteronism and metabolic alkalosis consistent with Gitelman Syndrome. The patient was found to have a previously unreported compound heterozygous mutation of T180K and L858H in the SLC12A3 gene, and Gitelman Syndrome was diagnosed. He was started on eplerenone to control serum potassium level. Alternative diagnoses should be considered when electrolyte imbalances persist after disease resolution.</p>
収録刊行物
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- 日医大誌
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日医大誌 86 (5), 301-306, 2019-10-15
日本医科大学医学会