Dietary Exposure Risk Assessment of Flonicamid and Its Effect on Constituents after Application in Lonicerae Japonicae Flos

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  • Li Jiaxin
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College
  • Wang Yujie
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College
  • Xue Jian
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College
  • Wang Pengsi
    Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medical College
  • Shi Shangmei
    Chinese Pharmacopoeia Commission

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  • Dietary Exposure Risk Assessment of Flonicamid and Its Effect on Constituents after Application in <i>Lonicerae Japonicae Flos</i>

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<p>To investigate the dietary exposure risk of flonicamid application on Lonicerae Japonicae Flos and the effect of flonicamid on constituents of Lonicerae Japonicae Flos, field experiments were conducted in Fengqiu, Henan province, and flonicamid residue in samples collected was detected by gas chromatography equipped with electron capture detector (GC-ECD). And chlorogenic acid and luteoloside were determined by HPLC. Dietary exposure risk assessment was conducted through comparing the estimated daily intake (EDI) which was calculated by using the consumed residual level along with the acceptable daily intake (ADI). The effect of flonicamid on chlorogenic acid and luteoloside were obtained by ANOVA statistical analysis and least significant difference (LSD)-t test. The results showed that the terminal-residue contents of flonicamid were under 1.6 mg kg−1. And risk quotient ranged from 0.0011 to 0.0028, indicating the long-term exposure to flonicamid residual through consumption of Lonicerae Japonicae Flos in consumers was relatively low. Flonicamid could suppress the generation of luteoloside, so it was not advised to be used in L. japonica flowering phase. The study aims at providing the useful suggestion on the reasonable flonicamid usage and the reference for the establishment of maximum residue limits (MRLs) of flonicamid in Lonicerae Japonicae Flos.</p>

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