Positive Selection in F-Box Domain (lpp0233) Encoded in <i>Legionella pneumophila</i> Strains
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- KENZAKA TAKEHIKO
- Faculty of Pharmacy, Osaka Ohtani University Graduate School of Pharmaceutical Sciences, Osaka University
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- YASUI MADOKA
- Graduate School of Pharmaceutical Sciences, Osaka University
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- BABA TAKASHI
- Graduate School of Pharmaceutical Sciences, Osaka University
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- NASU MASAO
- Faculty of Pharmacy, Osaka Ohtani University Graduate School of Pharmaceutical Sciences, Osaka University
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- TANI KATSUJI
- Faculty of Pharmacy, Osaka Ohtani University Graduate School of Pharmaceutical Sciences, Osaka University
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説明
<p> Recent studies have shown that the genome of Legionella pneumophila is characterized by many foreign genes from a variety of eukaryotes. The eukaryotic like proteins are known to play a role in its multiplication within host cells; however, their evolutionary genetics of L. pneumophila in environments is unknown. In this study, we examined the nonsynonymous/synonymous substitution rate of eukaryotic like domain encoding genes among L. pneumophila strains. In silico analysis revealed that the nonsynonymous/synonymous substitution rate in F-box domain gene (lpp0233) was higher than those in other eukaryotic like domain and protein encoding genes and housekeeping genes. The F-box domain gene sequences in L. pneumophila strains isolated from a natural hot spring were more diversified than those of previously known strains, owing to preferential positive selection.</p>
収録刊行物
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- Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ
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Ｂｉｏｃｏｎｔｒｏｌ Ｓｃｉｅｎｃｅ 23 (2), 53-59, 2018
日本防菌防黴学会
