Differentiation and proliferation of hematopoietic stem cells are regulated by C/EBPβ, a transcription factor required for emergency granulopoiesis

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  • HIRAI Hideyo
    Department of Transfusion Medicine and Cell Therapy, Kyoto University Hospital

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  • 緊急時好中球造血に必須の転写因子C/EBPβによる造血幹細胞の分化増殖制御
  • キンキュウジ コウチュウキュウ ゾウケツ ニ ヒッス ノ テンシャ インシ C/EBPv ニ ヨル ゾウケツ カンサイボウ ノ ブンカ ゾウショク セイギョ

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Abstract

<p>Under stress conditions such as infection, inflammation, and hematopoietic recovery following chemotherapy or transplantation, the hematopoietic system is required to meet the increasing demands, especially from myeloid cells. Therefore, an understanding of the molecular mechanism underlying stress hematopoiesis is clinically imperative. We previously showed that C/EBPβ, which is a transcription factor required for emergency granulopoiesis, plays a pivotal role at the level of hematopoietic stem/progenitor cells under stress conditions. Upon exposure to stress, the C/EBPβ protein is upregulated in the hematopoietic stem cells. A close examination of C/EBPβ knockout mice revealed that C/EBPβ regulates the proliferation and differentiation of hematopoietic stem cells at the cost of the self-renewing activity. Further elucidation of the functions and regulation of C/EBPβ in hematopoietic stem cells will facilitate an understanding of stress hematopoiesis.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 59 (6), 798-804, 2018

    The Japanese Society of Hematology

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