The effect of administration of fenbendazole on the microbial hindgut population of the horse

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  • CROTCH-HARVEY Laura
    Institute of Biological, Environmental and Rural Sciences, Edward Llwyd Building, Penglais Campus, Aberystwyth University, SY23 3DA, Wales, U.K. Equine, Pets and Livestock Animalcare, Glien House, Glien Road, Cillefwr Industrial Estate, SA31 3RB, Wales, U.K.
  • THOMAS Leigh-Anne
    Institute of Biological, Environmental and Rural Sciences, Edward Llwyd Building, Penglais Campus, Aberystwyth University, SY23 3DA, Wales, U.K.
  • WORGAN Hilary J.
    Institute of Biological, Environmental and Rural Sciences, Edward Llwyd Building, Penglais Campus, Aberystwyth University, SY23 3DA, Wales, U.K.
  • DOUGLAS Jamie-Leigh
    Institute of Biological, Environmental and Rural Sciences, Edward Llwyd Building, Penglais Campus, Aberystwyth University, SY23 3DA, Wales, U.K.
  • GILBY Diane E.
    Equine, Pets and Livestock Animalcare, Glien House, Glien Road, Cillefwr Industrial Estate, SA31 3RB, Wales, U.K.
  • MCEWAN Neil R.
    Institute of Biological, Environmental and Rural Sciences, Edward Llwyd Building, Penglais Campus, Aberystwyth University, SY23 3DA, Wales, U.K. School of Pharmacy and Life Sciences, Robert Gordon University, AB10 7GJ, Scotland, U.K.

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Anthelmintics are used as anti-worming agents. Although known to affect their target organisms, nothing has been published regarding their effect on other digestive tract organisms or on metabolites produced by them. The current work investigated effects of fenbendazole, a benzimidazole anthelmintic, on bacteria and ciliates in the equine digestive tract and on and their major metabolites. Animals receiving anthelmintic treatment had high faecal egg counts relative to controls. Analysis was performed over two weeks, with temporal differences detected in bacterial populations but with no other significant differences detected. This suggests fenbendazole has no detectable effect on organisms other than its targets. Moreover it does not appear to make a contribution to changing the resulting metabolome.

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