Localization of circadian oscillators that control activity onset and offset of mouse behavioral rhythm.

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  • YOSHIKAWA Tomoko
    Department of Anatomy and Neurobiology, Kindai University Faculty of Medicine

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  • マウスの日周活動リズム～活動開始・終了位相を制御する概日振動体の局在
  • マウス ノ ニッシュウ カツドウ リズム : カツドウ カイシ ・ シュウリョウ イソウ オ セイギョ スル ガイジツ シンドウタイ ノ キョクザイ

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Abstract

A model of two separate, but mutually coupled, circadian oscillators has been proposed to explain behavioral rhythm in nocturnal rodents: an evening (E) oscillator, which drives the activity onset and entrains to dusk, and a morning (M) oscillator, which drives the end of activity and entrains to dawn. Behavioral rhythm in mammals is controlled by circadian oscillator in the hypothalamic suprachiasmatic nucleus (SCN), indicating the E and M oscillators are located in the SCN. However, their localization in the SCN has not been shown. By using bioluminescence imaging of Period1-luciferase mouse we identified four regional oscillators in horizontal slices of the SCN. The first two regions are the respective sites for the E and M oscillators, and the third region is possibly a site for mediating photic signals to the former oscillators. The last region receives light information from the retina through the direct retinal projection. Histological analyses had indicated the SCN consists of two parts, core and shell. We identified the four regions by oscillatory function and light responsiveness. Our finding will be a valuable information for further study to reveal a regional function of the SCN.

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