新規脳梗塞治療薬ターゲットとしての脳内sodium-glucose transporterの可能性

DOI Web Site Web Site PubMed 参考文献60件

書誌事項

タイトル別名
  • Potential of the Cerebral Sodium-Glucose Transporter as a Novel Therapeutic Target in Cerebral Ischemia
  • Symposium Review 新規脳梗塞治療薬ターゲットとしての脳内sodium-glucose transporter の可能性
  • Symposium Review シンキ ノウ コウソク チリョウヤク ターゲット ト シテ ノ ノウナイ sodium-glucose transporter ノ カノウセイ

この論文をさがす

抄録

　Cerebral ischemic stress often induces a hyperglycemic condition. This postischemic hyperglycemia exacerbates the development of cerebral ischemic neuronal damage, although the mechanism of this exacerbation remains to be clarified. We previously discovered that the cerebral sodium-glucose transporter (SGLT) was closely involved in the development of cerebral ischemic neuronal damage. SGLT is a member of the glucose transporter family and moves glucose together with sodium ions. SGLT-1, -3, -4, and -6 are distributed in the brain. We conducted further experiments to elucidate the detailed mechanism of the exacerbation of cerebral ischemia by cerebral SGLT. The results clarified: 1) the relationship between cerebral SGLT and postischemic hyperglycemia; 2) the involvement of cerebral SGLT-1 (a cerebral SGLT isoform) in cerebral ischemic neuronal damage; and 3) the effects of sodium influx through cerebral SGLT on the development of cerebral ischemic neuronal damage. This paper presents our data on the involvement of cerebral SGLT in the exacerbation of cerebral ischemic neuronal damage.<br>

収録刊行物

  • 薬学雑誌

    薬学雑誌 138 (7), 955-962, 2018-07-01

    公益社団法人 日本薬学会

参考文献 (60)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ