Introduction of a Polar Functional Group to the Lipid Tail of 4-<i>epi</i>-Jaspine B Affects Sphingosine Kinase Isoform Selectivity

DOI Web Site Web Site PubMed 1 Citations 32 References

Bibliographic Information

Other Title
  • Highlighted Paper selected by Editor-in-Chief : Introduction of a Polar Functional Group to the Lipid Tail of 4-epi-Jaspine B Affects Sphingosine Kinase Isoform Selectivity

Search this article

Abstract

<p>Sphingosine kinases (SphKs) are key enzymes that regulate sphingosine 1-phosphate production levels, and are involved in a range of cellular processes. Focusing on a hydrophilic residue in the hydrophobic binding pocket of SphKs, we designed and synthesized 4-epi-jaspine B derivatives containing a polar functional group in the lipid tail. A biological evaluation revealed that the introduction of ether groups to the lipid tail of 4-epi-jaspine B modulated its isoform selectivity toward SphKs.</p>

Journal

Citations (1)*help

See more

References(32)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top