Morphological analysis of cephalic vasculogenesis in mouse embryos

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  • Saito Miho
    Division of Human Embryology, Department of Anatomy, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Kimura Eiji
    Division of Human Embryology, Department of Anatomy, School of Medicine, Iwate Medical University, Yahaba, Japan
  • Hitomi Jiro
    Division of Human Embryology, Department of Anatomy, School of Medicine, Iwate Medical University, Yahaba, Japan

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Other Title
  • マウス胚の頭部初期血管系の形成過程の形態学的解析
  • マウスハイ ノ トウブ ショキ ケッカンケイ ノ ケイセイ カテイ ノ ケイタイガクテキ カイセキ

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Attempts have been made to clarify cephalic vascular development in mammals including humans, but the details remain unresolved. In this study, we investigated the vascular development in the stage of neural plate and head process formation using immunostaining of serial sections and nearly transparent whole-bodies with PECAM-1 antibody, which enabled us to visualize endothelial cells in the early stage of mouse embryos. We succeeded in capturing images of the dorsal aorta ahead of the junction with the first aortic arch, of which the frontal portion showed an expanded lumen and endothelium attached to the cephalic neural plate. We also demonstrated that, just beneath the neural plate, the dorsal-lateral vasculature elongated from the front portion, which would develop before the vasculogenesis of the dorsal aorta beside the foregut pocket. These detailed morphological data will help elucidate the mechanism of cephalic vasculature development.

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