Preparation of Polymeric Porous Scaffolds for Regenerative Medicine

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  • Chen Guoping
    Tissue Regeneration Materials Group, Research Center for Functional Materials, National Institute for Materials Science
  • Kwazoe Naoki
    Tissue Regeneration Materials Group, Research Center for Functional Materials, National Institute for Materials Science

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  • 再生医療のための高分子多孔質材料の作製
  • サイセイ イリョウ ノ タメ ノ コウブンシ タコウシツ ザイリョウ ノ サクセイ

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Abstract

Porous scaffolds play an important role in regenerative medicine to provide necessary space for cell assembly and to control cell functions for regeneration of functional tissues and organs. Biodegradable synthetic polymers such as poly(L–lactic acid) (PLLA) and poly(lactic acid–co–glycolic acid) (PLGA) and naturally derived polymers such as collagen and gelatin have been most frequently used for preparation of biodegradable porous scaffolds. To improve the porous structures of scaffolds, we have developed a method using pre–prepared ice particulates as a porogen material. Free ice particulates can be used to increase pore interconnectivity while embossing ice particulates can be used to make surface pores open and to prepare micropatterned pore structures. The open and interconnected pore structures can facilitate homogenous cell distribution and therefore promote functional tissue regeneration. The micropatterned porous scaffolds can be used to control cell orientation and to promote cell bundle formation. We have also developed a hybridization method to combine the advantages of both biodegradable synthetic polymers and naturally derived polymers. The hybrid scaffolds have high mechanical strength, easy handling, good water wettability and cell interaction. The polymeric porous scaffolds have been used for regeneration of cartilage, bone, skin, muscle and ligament. This review summarizes these polymeric porous scaffolds prepared by ice particulates and hybridization and their applications for regenerative medicine.

Journal

  • MEMBRANE

    MEMBRANE 43 (5), 215-223, 2018

    THE MEMBRANE SOCIETY OF JAPAN

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