Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)
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- Seto-Yukimura Ruriko
- Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science
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- Ogawa Emiko
- Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science Health Administration Center, Shiga University of Medical Science
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- Hisamatsu Takashi
- Department of Public Health, Shiga University of Medical Science Department of Environmental Medicine and Public Health, Faculty of Medicine, Shimane University
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- Torii Sayuki
- Department of Public Health, Shiga University of Medical Science
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- Shiino Akihiko
- Molecular Neuroscience Research Center, Shiga University of Medical Science
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- Nozaki Kazuhiko
- Department of Neurosurgery, Shiga University of Medical Science
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- Fujiyoshi Akira
- Department of Public Health, Shiga University of Medical Science
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- Miura Katsuyuki
- Department of Public Health, Shiga University of Medical Science Center for Epidemiologic Research in Asia, Shiga University of Medical Science
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- Nakano Yasutaka
- Division of Respiratory Medicine, Department of Internal Medicine, Shiga University of Medical Science
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- Ueshima Hirotsugu
- Department of Public Health, Shiga University of Medical Science Center for Epidemiologic Research in Asia, Shiga University of Medical Science
Description
<p>Aim: We aimed to investigate the association between reduced lung function and cerebral small vessel diseases via cranial magnetic resonance imaging (MRI) in the cross-sectional study of the general Japanese population.</p><p>Methods: We recruited participants aged ≥40 years from the general population of a single city in Japan. We clarified the comorbidities and treatments, smoking habits, second-hand smoke exposure, current alcohol consumption, education level, exercise habits, and occupation. The pulmonary function test was performed to assess the forced expiratory volume in 1 second (FEV1) % predicted and forced vital capacity (FVC) % predicted values. Cranial MRI was performed to evaluate the white matter lesions (WMLs) and lacunar infarcts. We examined the association of the WMLs and lacunar infarcts with a 1-standard deviation (SD) lower in the FEV1 % predicted and FVC % predicted, on the basis of the smoking status.</p><p>Results: A total of 473 men were examined. The association of WMLs and lacunar infarcts with the spirometry-based indices were significant only in never smokers. The association between lung function impairment and cerebral small vessel disease did not change after further adjusting for second-hand smoke exposure.</p><p>Conclusion: In a community-based sample of Japanese men, we found an association between reduced lung function and WMLs and lacunar infarcts in never smokers.</p>
Journal
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- Journal of Atherosclerosis and Thrombosis
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Journal of Atherosclerosis and Thrombosis 25 (10), 1009-1021, 2018-10-01
Japan Atherosclerosis Society