Design of Favorable Compound Libraries for Biologists

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  • 生化学者に好まれる化合物ライブラリーの構築を目指して
  • ラウンジ 生化学者に好まれる化合物ライブラリーの構築を目指して
  • ラウンジ セイカガクシャ ニ コノマレル カゴウブツ ライブラリー ノ コウチク オ メザシテ

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Abstract

<p>The compound libraries visualized by organic chemists do not conform with those by biologists. Biologists prefer libraries that contain diverse “drug-like” compounds. In this article, we have introduced a method for constructing compound libraries with drug-likeness and diversity by utilizing “drug-likeness indexes”. The indexes are useful for the quantification of structural features of compounds and for the design of diverse-orientated libraries. In addition, we characterized natural products through the use of drug-likeness indexes, and described the usage of those for library constructions.</p>

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