Comparative study for carcinogenicity of 7 different multi-wall carbon nanotubes with different physicochemical characteristics by a single intraperitoneal injection in male Fischer 344 rats

DOI Web Site Web Site PubMed 被引用文献5件 参考文献45件
  • Sakamoto Yoshimitsu
    Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
  • Hojo Motoki
    Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
  • Kosugi Yuki
    Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
  • Watanabe Kimiyo
    Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
  • Hirose Akihiko
    Division of Risk Assessment, Biological Safety Research Center, National Institute of Health Sciences
  • Inomata Akiko
    Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
  • Suzuki Toshinari
    Department of Pharmaceutical and Environmental Sciences, Tokyo Metropolitan Institute of Public Health
  • Nakae Dai
    Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences, Tokyo University of Agriculture

この論文をさがす

説明

<p>The present study comparatively examined carcinogenicity of 7 different multi-wall carbon nanotubes (MWCNTs) with different physicochemical characteristics. Physicochemical characteristics of MWCNTs (referred to as M-, N-, WL-, SD1-, WS-, SD2- and T-CNTs in the present study) were determined using scanning electron and light microscopes and a collision type inductively coupled plasma mass spectrometer. Male Fischer 344 rats (10 weeks old, 15 animals per group) were administered MWCNTs at a single intraperitoneal dose of 1 mg/kg body weight, and sacrificed up to 52 weeks after the commencement. Fibers of M-, N-, WL- and SD1-CNTs were straight and acicular in shape, and contained few agglomerates. They were relatively long (38-59% of fibers were longer than 5 μm) and thick (33% to more than 70% of fibers were thicker than 60 nm). All of these 4 MWCNTs induced mesotheliomas at absolute incidences of 100%. Fibers of WS-, SD2- and T-CNTs were curled and tightly tangled to form frequent agglomerates. They were relatively short and thin (more than 90% of measured fibers were thinner than 50 nm). WS- CNT did not induce mesothelioma, and only one of 15 rat given SD2- or T-CNT developed tumor. Any correlations existed between the metal content and neither the size or form of fibers, nor the carcinogenicity. It is thus indicated that the physicochemical characteristics of MWCNTs are critical for their carcinogenicity. The straight and acicular shape without frequent agglomerates, and the relatively long and thick size, but not the iron content, may be critical factors. The present data can contribute to the risk management, practical use and social acceptance of MWCNTs.</p>

収録刊行物

被引用文献 (5)*注記

もっと見る

参考文献 (45)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ