Present status of liver transplantation in the National Center for Child Health and Development: Single-center experience of 500 liver transplantations

DOI
  • KASAHARA Mureo
    Organ Transplantation Center, National Center for Child Health and Development
  • UCHIDA Hajime
    Organ Transplantation Center, National Center for Child Health and Development
  • SASAKI Kengo
    Organ Transplantation Center, National Center for Child Health and Development
  • HIRATA Yoshihiro
    Organ Transplantation Center, National Center for Child Health and Development
  • TAKEDA Masahiro
    Organ Transplantation Center, National Center for Child Health and Development
  • KATONO Masami
    Organ Transplantation Center, National Center for Child Health and Development
  • KUBOTA Tomomi
    Organ Transplantation Center, National Center for Child Health and Development
  • NAKAZATO Yayoi
    Organ Transplantation Center, National Center for Child Health and Development
  • FUKUDA Akinari
    Organ Transplantation Center, National Center for Child Health and Development
  • SAKAMOTO Seisuke
    Organ Transplantation Center, National Center for Child Health and Development

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Other Title
  • 国立成育医療研究センターにおける肝移植500例の成績

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Abstract

<p>【Purpose】 We reviewed our experience of liver transplantation in the National Center for Child Health and Development and report the results herein.</p><p>【Subjects and methods】 We have handled 500 cases of liver transplantation from November 2005 through March 2018 in the National Center for Child Health and Development. Variables including indication of liver transplantation and immunological outcome were reviewed.</p><p>【Results】 There were 469 living donor, 27 deceased and 4 domino liver transplantations in the study period. The indication for liver transplantation was cholestatic liver disease in 48.0%, followed by metabolic liver disease in 22.0% and acute liver failure in 12.6%. The mean age of recipients was 4.0±5.5 years and body weight was 14.9±13.3 kg. Immunosuppression consisted of tacrolimus and low-dose steroids. The incidence of acute cellular rejection was 42.0%. The 10-year patient survival was 90.2%.</p><p>【Conclusion】 Satisfactory results can be achieved in the liver transplantation program in the National Center for Child Health and Development. Deceased donor liver transplantation, patients with acute liver failure and re-transplantation shows significantly lower patient survival. We conclude that liver transplantation is a safe and effective treatment modality together with proper indication and excellent management strategy. The significant factors affecting survival may be overcome by the technical and immunological refinements that have occurred in recent years.</p>

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