Cutaneous Findings of Crimean-Congo Hemorrhagic Fever: a Study of 269 Cases

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  • Duygu Fazilet
    Department of Infectious Diseases and Clinical Microbiology, Ankara Oncology Training and Research Hospital
  • Sari Tugba
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Pamukkale University
  • Gunal Ozgur
    Department of Infectious Diseases and Clinical Microbiology, Samsun Training and Research Hospital
  • Barut Sener
    Department of Infectious Diseases and Clinical Microbiology, Faculty of Medicine, Gaziosmanpasa University
  • Atay Ayfer
    Department of Infectious Diseases and Clinical Microbiology, Bakirköy Dr. Sadi Konuk Training and Research Hospital
  • Aytekin Feyza
    Department of Infectious Diseases and Clinical Microbiology, Ministry of Health-Giresun University Dr. A. Ilhan Ozdemir Training and Research Hospital

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<p>Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic viral disease. We aimed to investigate the cutaneous manifestations of CCHF and reveal their associations with fatality. Two hundred and sixty-nine patients diagnosed with CCHF were assessed. Skin findings were observed in 170 (63.2%) patients. A facial rash was the most common cutaneous finding (n = 82, 30.5%). In severe cases, hemorrhagic cutaneous manifestations (petechiae and ecchymoses) were recognized. A statistically significant correlation was obtained between cutaneous manifestations and fatality, and it was determined that there was a strong positive correlation between fatality and ecchymosis (r = 567, p < 0.001). In addition, a logistic regression analysis was performed, and death occurred 4.69 times more in those with skin signs than in those without. We hypothesize that CCHF patients with ecchymosis are at the highest risk and that cutaneous findings can contribute to the prognosis of CCHF.</p>

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