Clinical investigations of concurrent chemoradiotherapy combined with 3-Weekly high-dose cisplatin

DOI Web Site 12 References
  • Iuchi Hiroyuki
    Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences
  • Ito Kotoko
    Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima City Hospital
  • Matsumoto Hayato
    Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences National Hospital Organization Kagoshima Medical Center
  • Hanamure Yutaka
    Kagoshima City Hospital
  • Matsuzaki Tsutomu
    National Hospital Organization Kagoshima Medical Center
  • Kurono Yuichi
    Department of Otolaryngology, Head and Neck Surgery, Kagoshima University Graduate School of Medical and Dental Sciences

Bibliographic Information

Other Title
  • 3-Weekly高用量シスプラチン併用放射線化学療法の臨床的検討
  • —2回目のシスプラチン投与に注目して—
  • ―focused on second injection of cisplatin―

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Abstract

A retrospective review of 43 patients who received high-dose cisplatin（CDDP）（100mg/m2; 100％ dose）with concurrent chemoradiotherapy（CCRT）from May 2016 to May 2018 was performed. We divided the patients into two groups: in the second CDDP（＋）group it was possible to administer the second CDDP（100mg/m2; 100％ dose）3 weeks later, whereas in the second CDDP（−）group such administration was not possible. In the second CDDP（−）group, incidence of leukopenia was 96％ and renal dysfunction was 11％. Compared to the second CDDP（＋）group, in the second CDDP（−）group, albumin（Alb）was significantly lower before the first administration of CDDP, and the modified Glasgow Prognostic Score（mGPS）was higher. Furthermore, comparing dietary intake, the second CDDP（＋）group had higher average meal intake per day. Nutritional management during high-dose CDDP（100mg/m2; 100％ dose）is an important factor for the continuation of treatment.

Journal

  • Toukeibu Gan

    Toukeibu Gan 44 (3), 305-309, 2018

    Japan Society for Head and Neck Cancer

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