Revision and problems of new TNM classification （eighth edition） for oropharyngeal cancer

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  • 新TNM分類（第8版）の改定点と問題点
  • —中咽頭癌の改定点と問題点—

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In the revised TNM classification （AJCC/UICC 8th） of 2017, HPV-related oropharyngeal carcinoma （OPC） is defined separately from conventional head and neck cancers. Immunohistochemistry for p16 overexpression has emerged as a surrogate biomarker for HPV-related OPC. All oropharyngeal carcinomas should be tested for p16 immunohistochemistry. Oropharyngeal carcinomas without p16 testing are staged using the p16-negative staging system. Patients classified as N1-N2b using the 7th edition are classified as N1 in p16-positive OPC in the 8th edition. Categories T4a and T4b are defined as T4 without distinction. The classifications cN and pN are different for N classifications. Primary unknown p16 positive squamous cell carcinoma is classified as T0 for HPV-related OPC. The applicability of the new TNM classification for HPV-related OPC is unclear. Future analysis to validate the applicability of the new TNM classification is warranted.

Journal

  • Toukeibu Gan

    Toukeibu Gan 44 (3), 253-257, 2018

    Japan Society for Head and Neck Cancer

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