Skin Moisturizing Effect through the Stimulation of the Cornified Cell Envelope Formation by Bis-Glyceryl Ascorbate
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- Doi Misaki
- Seiwa Kasei Co., Ltd.
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- Nakamura Sayaka
- Seiwa Kasei Co., Ltd.
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- Taira Norihisa
- Seiwa Kasei Co., Ltd.
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- Katsuyama Yushi
- Seiwa Kasei Co., Ltd.
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- Masaki Hitoshi
- School of Bioscience and Biotechnology, Tokyo University of Technology
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- Yoshioka Masato
- Seiwa Kasei Co., Ltd.
Bibliographic Information
- Other Title
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- ビスグリセリルアスコルビン酸のコーニファイドセルエンベロープ形成促進を介した皮膚保湿作用
- ビスグリセリルアスコルビンサン ノ コーニファイドセルエンベロープ ケイセイ ソクシン オ カイシタ ヒフホシツサヨウ
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Abstract
<p>Ascorbic acid (AsA) is well-known as a multifunctional water soluble vitamin that shows antipigmentation effects in epidermal melanocytes and stimulates collagen synthesis in dermal fibroblasts. However, AsA has some disadvantages in cosmetic formulations since it is quite unstable in aqueous solutions and emulsions. To improve the stability of AsA in cosmetic formulations, we developed a novel AsA derivative, bis-glyceryl ascorbate (VC-DG), which introduces 2 glycerol groups into AsA, and confirmed that VC-DG has a higher stability than AsA and maintains its bioactivities as well as AsA. In this study, we evaluated the skin moisturizing effects of VC-DG focusing on the cornified cell envelope (CE) to develop its unique biological activities. As the results, VC-DG up-regulated the mRNA and protein expression levels of CE-related substances, such as involucrin, loricrin and transglutaminase-1, which in turn significantly increased CE formation in normal human epidermal keratinocytes. Additionally, topical application of VC-DG increased the protein expression levels of involucrin, loricrin and transglutaminase-1 in the spinous and/or granular cell layers of reconstructed human epidermal equivalents. In a human volunteer test, the application of VC-DG increased the skin surface water content. Therefore, we consider VC-DG to be an effective ingredient that improves skin hydration through enhancing CE formation.</p>
Journal
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- Journal of Society of Cosmetic Chemists of Japan
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Journal of Society of Cosmetic Chemists of Japan 52 (4), 275-281, 2018-12-20
The Society of Cosmetic Chemists of Japan
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Keywords
Details 詳細情報について
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- CRID
- 1390845713032582272
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- NII Article ID
- 130007535795
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- NII Book ID
- AN00101606
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- ISSN
- 18844146
- 03875253
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- NDL BIB ID
- 029428190
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed