Survey of Genotypes on Glaucoma Susceptibility Gene <i>SRBD1</i> in Shiba Inu

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  • 柴犬における緑内障感受性遺伝子<i>SRBD1</i> の遺伝子型調査
  • 柴犬における緑内障感受性遺伝子SRBD1の遺伝子型調査
  • シバイヌ ニ オケル リョクナイショウ カンジュセイ イデンシ SRBD1 ノ イデンシガタ チョウサ

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Abstract

<p>We investigated the association between the incidence of glaucoma in Shiba Inu and three single-nucleotide polymorphisms (SNPs) of glaucoma candidate gene SRBD1 as a survey at six referral hospitals for ophthalmic diseases in small animals. Our analysis showed that the risk of glaucoma in Shiba Inu carrying the homologous risk allele rs8655283 was 3.45 times higher (P＜0.05) compared to those carrying the homologous non-risk allele. Carrying the homologous risk allele rs22018514 was 4.32 times higher (P＜0.01) than the homologous non-risk allele. Carrying the homogeneous or heterogeneous allele of rs22018513 was 10.33 times (P＜0.01) or 6.14 times (P＜0.05) higher than the non-risk homologous allele, respectively. We anticipate that the SNP genotyping data from the results of this study can be used in genetic testing to precisely determine whether a dog has glaucoma and to predict whether it will develop glaucoma.</p>

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