Stream from antibiotics research to chemical biology research

DOI

Bibliographic Information

Other Title
  • 抗生物質研究からケミカルバイオロジー研究への変遷

Abstract

<p>In 1950s, it was a golden age of antibiotic research and many medicines have been developed from microbial metabolites. However, since 1990s, natural product screening has been diminished and the high-throughput screening (HTS) has drawn attention. Namely, chemical libraries synthesized by combinatorial chemistry deprived drug screening of natural products. Natural products have drawbacks, such as time-consuming for the sample-preparation and difficulties in synthesis of derivatives. Here, we have to reconfirm the weaknesses and strengths of natural products, and to create a new strategy for drug screening from natural products. In this paper, I would like to propose a remedy for the problems of these natural products drug discovery.</p>

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 25 (1), 16-21, 2015-02-01

    The Pharmaceutical Society of Japan

Keywords

Details 詳細情報について

  • CRID
    1390845713035337088
  • NII Article ID
    130007542583
  • DOI
    10.14894/medchem.25.1_16
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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