Development of versatile solid material for affinity resins and its application for the target identification of bioactive compounds
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- Tanaka Akito
- Department of Pharmacy, Hyogo University of Health Sciences
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- Mabuchi Miyuki
- Department of Pharmacy, Hyogo University of Health Sciences
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- Shimizu Tadashi
- Department of Pharmacy, Hyogo University of Health Sciences
Bibliographic Information
- Other Title
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- アフィニティ樹脂を用いた生理活性物質のターゲット探索
- ―化学的に安定で非特異的タンパク質吸着が少ない汎用的固相担体AquaFirmus<sup>TM</sup>開発―
Abstract
<p>The identification of target proteins for bioactive compounds such as drugs, natural products and toxins, is an essential component of modern life sciences and chemical biology. While affinity chromatography matrices are one of the major tools for achieving this goal, it is of ten difficult to identify specific binding proteins owing to a preponderance of non-specific binding proteins. We herein exhibit development of versatile solid material for affinity resins that is chemically stable and hydrophilic enough for reduction of the non-specific protein absorptions. Some successful results from our labs are also shown.</p>
Journal
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- MEDCHEM NEWS
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MEDCHEM NEWS 25 (1), 38-44, 2015-02-01
The Pharmaceutical Society of Japan
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Details
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- CRID
- 1390845713036655232
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- NII Article ID
- 130007542563
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- ISSN
- 24328626
- 24328618
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed