Development of versatile solid material for affinity resins and its application for the target identification of bioactive compounds

DOI

Bibliographic Information

Other Title
  • アフィニティ樹脂を用いた生理活性物質のターゲット探索
  • ―化学的に安定で非特異的タンパク質吸着が少ない汎用的固相担体AquaFirmus<sup>TM</sup>開発―

Abstract

<p>The identification of target proteins for bioactive compounds such as drugs, natural products and toxins, is an essential component of modern life sciences and chemical biology. While affinity chromatography matrices are one of the major tools for achieving this goal, it is of ten difficult to identify specific binding proteins owing to a preponderance of non-specific binding proteins. We herein exhibit development of versatile solid material for affinity resins that is chemically stable and hydrophilic enough for reduction of the non-specific protein absorptions. Some successful results from our labs are also shown.</p>

Journal

  • MEDCHEM NEWS

    MEDCHEM NEWS 25 (1), 38-44, 2015-02-01

    The Pharmaceutical Society of Japan

Keywords

Details

  • CRID
    1390845713036655232
  • NII Article ID
    130007542563
  • DOI
    10.14894/medchem.25.1_38
  • ISSN
    24328626
    24328618
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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