Two Cases of Lynch Syndrome That Were Diagnosed and Resected as Duodenal Cancer

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  • Abe Kodai
    Department of Surgery, Kitasato Institute Hospital, Kitasato University
  • Suzuki Keiichi
    Department of Surgery, Kitasato Institute Hospital, Kitasato University
  • Yahagi Masashi
    Department of Surgery, Kitasato Institute Hospital, Kitasato University
  • Murata Takeru
    Department of Surgery, Kitasato Institute Hospital, Kitasato University
  • Sako Hiroyuki
    Department of Surgery, Kitasato Institute Hospital, Kitasato University
  • Ishii Yoshiyuki
    Department of Surgery, Kitasato Institute Hospital, Kitasato University
  • Hara Atsuko
    Department of Diagnostic Pathology, Kitasato Institute Hospital, Kitasato University

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  • 十二指腸癌を契機に診断し切除しえたLynch症候群の2例

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<p>This report describes a 60-year-old man with a history of colorectal cancer, renal cell carcinoma, bladder cancer, and prostate cancer. His duodenal cancer was discovered as the sixth cancer and was treated by pancreaticoduodenectomy. He was given a diagnosis of Lynch syndrome based on his status as a carrier of pathogenic mutations in the MSH2 gene, which is a mismatch repair (MMR) gene. This report also describes a 75-year-old man with a history of multiple operations for colorectal cancer and gastric cancer. His duodenal cancer was discovered as the seventh cancer and was treated by pancreaticoduodenectomy. He was also given a diagnosis of Lynch syndrome based on his status as a carrier of pathogenic mutations in the MLH1 gene, which is an MMR gene. Lynch syndrome is a disease with autosomal dominant inheritance and is caused by mutations in MMR genes. The cumulative incidence of small bowel cancer, including duodenal cancer, is low; it is estimated to range from 2.5% to 4.3%. The guidelines for hereditary colorectal cancer recommend that surveillance in patients with gastrointestinal cancer should include endoscopic examinations every 1 to 2 years. However, in older patients such as those described herein, the risk of duodenal cancer should be kept in mind and surveillance should be performed more carefully and precisely.</p>

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