Effect of Ocimum basilicum, Ocimum selloi, and Rosmarinic Acid on Cerebral Vascular Damage in a Chronic Hypertension Model

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  • Alegría-Herrera Elian
    Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS) Doctorado en Ciencias Biológicas y de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa Departamento Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa
  • Herrera-Ruiz Maribel
    Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS)
  • Román-Ramos Rubén
    Departamento Ciencias de la Salud, División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa
  • Zamilpa Alejandro
    Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS)
  • Santillán-Urquiza Mayra Alejandra
    Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS)
  • Aguilar María Isabel
    Laboratorio 111, Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México
  • Avilés-Flores Margarita
    INAH-Morelos
  • Fuentes-Mata Macrina
    INAH-Morelos
  • Jiménez-Ferrer Enrique
    Centro de Investigación Biomédica del Sur, Instituto Mexicano del Seguro Social (IMSS)

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タイトル別名
  • Effect of <i>Ocimum basilicum</i>, <i>Ocimum selloi</i>, and Rosmarinic Acid on Cerebral Vascular Damage in a Chronic Hypertension Model

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<p>The main objective of treatment against hypertension is not only to reduce blood pressure levels, but also to reduce vascular risk in general. In the present work, administering angiotensin II (AGII; 0.2 µg/kg intraperitoneally (i.p.) for 12 weeks) activates the hypothalamic–pituitary–adrenal (HPA) axis, which caused an increase in corticosterone levels, as well as in proinflammatory cytokines (interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α)) and macrophage chemotactic protein 1 (MCP-1), and decreased anti-inflammatory cytokines (interleukin 10 (IL-10) and interleukin 4 (IL-4)). On observing the behavior in the different models, an anxiogenic effect (elevated plus maze (EPM)) and cognitive impairment (water Morris maze (WMM)) was observed in animals with AGII. By administering organic extracts from Ocimum basilicum (Oba-EtOAc) and Ocimum selloi (Ose-EtOAc), and some doses of rosmarinic acid (RA) (6 weeks per os (p.o.)), the damage caused by AGII was stopped by re-establishing corticosterone serum levels and by decreasing the proinflammatory cytokines and MCP-1.</p>

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