The comparative teratogenicity of actinomycin D in SD-JCL (Sprague-Dawley) rats and ICR-JCL mice

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  • SASAKI Hiroshi
    Nippon Merck-Banyu Co Ltd Research Laboratories The Research Institute of Environmental Medicine Nagoya University

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  • ラットおよびマウス胚におよぼすActinomycin Dの催奇形作用の比較

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Abstract

A single high dose of actinomycin D was given to the Sprague-Dawley rats and ICR-JCL mice intraperitoneally during the period of organogenesis. While LD_<50> Values reported in non-pregnant rats were smaller than those in mice, i. e., the toxic effects of actinomycin D in the rats were much greater than those in the mice but the lethal effects of the drug for the rat fetuses were much lower than for the mice fetuses. The fluctuation in the mortality in the mouse fetuses per mother seemed to be larger than those in the rat fetuses. The malformations in the rat fetuses were those of the central nervous system, eye, viscera, etc., while in the mouse such a pattern of malformations was not detectable. The incidence of malformed rat fetuses were much higher than in the mouse. In case of the ICR-JCL mice, a single injection using the effective dose range presented maximal teratogenic and lethal effects when the chemical was given on day 8 of gestation. In case of the Sprague-Dawley rat, lethal effects to the fetuses presented a maximum incidence when injected on day 9 and the teratogenicity was revealed to be the most apparent when it was given on day 8.

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