THE EXAMINATION OF IGE AND PERIPHERAL BLOOD MONONUCLEAR CELLS RESPONSES TO FLOUR EXTRACTS IN A BAKER'S RHINITIS PATIENT

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  • Haruna Takenori
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
  • Okano Mitsuhiro
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine
  • Fujiwara Tazuko
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Higaki Takaya
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Kariya Shin
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
  • Makihara Seiichiro
    Department of Otorhinolaryngology, Kagawa Rosai Hospital
  • Kanai Kengo
    Department of Otorhinolaryngology, Kagawa Prefectural Central Hospital
  • Tachibana Tomoyasu
    Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
  • Matsuyama Yuko
    Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
  • Komatsubara Yasutoshi
    Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
  • Naoi Yuto
    Department of Otolaryngology, Japanese Red Cross Society Himeji Hospital
  • Nishizaki Kazunori
    Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

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Other Title
  • Baker's rhinitis症例における小麦粉抗原に対するIgEおよび末梢血単核細胞応答の解析の試み
  • Baker's rhinitis症例における小麦粉抗原に対するlgEおよび末梢血単核細胞応答の解析の試み
  • Baker's rhinitis ショウレイ ニ オケル コムギコ コウゲン ニ タイスル lgE オヨビ マッショウケツタンカク サイボウ オウトウ ノ カイセキ ノ ココロミ

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Abstract

<p>Background: Baker's rhinitis is a kind of occupational allergic rhinitis mainly caused by intranasal exposure to wheat and/or rye flour in bakery workers. Continuous exposure to flour may induce the onset of asthma in these patients.</p><p>Method: We experienced a case of 34-year-old male with baker's rhinitis without asthma, and investigated responses of IgE and peripheral blood mononuclear cells (PBMCs) to flour extracts used in the bakery in practice.</p><p>Result: In the immunoblotting, the patient's IgE reacted with 18 and 30kDa molecules in the extracts of 6 flours used in the bakery. The patient's PBMC produced a substantial amount of IL-5 and IL-13 in response to these flour extracts.</p><p>Conclusion: It is suggested that water/salt soluble components of wheat flour selectively induce type 2 cytokines production in baker's rhinitis.</p>

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